The impact of androgen deprivation therapy on the lipid profile in patients with prostate carcinoma

Abstract Background Dyslipidemia is directly related to morbidity and mortality in elderly prostate carcinoma patients. The purpose of this study was evaluate the effects androgen deprivation therapy (ADT) on lipid profile among Indian patients with locally advanced metastatic carcinoma. Methods prospective database patients, who received ADT whose data for first two years treatment available, were divided into groups retrospective analysis: Group A are those had undergone bilateral orchidectomy, while group B luteinizing hormone-releasing hormone agonist (LHRHa). analyzed include baseline characteristics, prostate-specific antigen (PSA), profile. Results total 69 eligible groups: A—29 B—40 Patients both reported a significant decrease mean serum PSA level from commencement remained close nadir till 24 months. In parameters except high-density lipoprotein cholesterol showed statistically insignificant deterioration maximum impact at 6 Among (11.9%), triglycerides (22.2%), low-density (21.1%) increased significantly months returned near 12 thereafter persisted similar level. very (15.5%) also then gradual decline follow-up. Conclusions LHRH used as leads but clinically temporary worsening